T-Box 1 anticorps (Middle Region)

N° du produit ABIN2777911

Cet anticorps anti-T-Box 1 Polyclonal Lapin (ABIN2777911) détecte spécifiquement T-Box 1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Cobaye, Lapin et Cheval.

Aperçu rapide pour T-Box 1 anticorps (Middle Region) (ABIN2777911)

Antigène: T-Box 1 (TBX1)

Reactivité: Humain, Souris, Rat, Cobaye, Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp T-Box 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-T-Box 1 anticorps

Épitope: Middle Region

Fonction: TBX1 Antibody - middle region

Séquence: PVASPTQPSG TEKGGHVLKD KEVKAETSRN TPEREVELLR DAGGCVNLGL

Homologie: Guinea Pig: 85%, Horse: 77%, Human: 100%, Mouse: 77%, Rabbit: 85%, Rat: 85%

Attributs du produit: This is a rabbit polyclonal antibody against TBX1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human TBX1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8113346

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur T-Box 1

Antigène: T-Box 1 (TBX1)

Autre désignation: TBX1

Sujet:

Background Information: TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX1 product shares 98 % amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where TBX1 has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98 % amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene Name: T-box 1

Alternative Symbols: DGS, TGA, VCF, CAFS, CTHM, DGCR, DORV, VCFS, TBX1C, CATCH22

Protein Name: T-box transcription factor TBX1

Poids moléculaire: 43kDa

ID gène: 6899

NCBI Accession: NP_542377

UniProt: O43435

Pathways: Retinoic Acid Receptor Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation