TCF7L2 anticorps (N-Term)

N° du produit ABIN2777926

L’anticorps Lapin Polyclonal anti-TCF7L2 a été validé pour WB. Il convient pour détecter TCF7L2 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Poisson zèbre (Danio rerio), Porc et Cobaye.

Aperçu rapide pour TCF7L2 anticorps (N-Term) (ABIN2777926)

Antigène: TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Poisson zèbre (Danio rerio), Porc, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TCF7L2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TCF7L2 anticorps

Épitope: N-Term

Séquence: MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN

Homologie: Cow: 100%, Guinea Pig: 79%, Human: 100%, Mouse: 93%, Pig: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against TCF7L2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human TCF7L2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 596 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TCF7L2

Antigène: TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))

Autre désignation: TCF7L2

Sujet: The TCL7L2 is a high mobility group (HMG) box-containing transcription factor implicated in blood glucose homeostasis. The study of Yi et al. suggested that TCL7L2 acts through regulation of proglucagon through repression of the proglucagon gene in enteroendocrine cells via the Wnt signaling pathway. The TCL7L2 gene product is a high mobility group (HMG) box-containing transcription factor implicated in blood glucose homeostasis. The study of Yi et al. (2005) [PubMed 15525634] suggested that TCL7L2 acts through regulation of proglucagon (MIM 138030) through repression of the proglucagon gene in enteroendocrine cells via the Wnt signaling pathway.[supplied by OMIM]. Sequence Note: This gene (TCF7L2, alias TCF-4) is distinct from TCF4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-202 DA473655.1 1-202 203-251 Y11306.2 3-51 252-1252 AK225809.1 256-1256 1253-1305 Y11306.2 1053-1105 1306-1756 AK225809.1 1310-1760 1757-1811 Y11306.2 1557-1611 1812-2652 AK225809.1 1765-2605
Alias Symbols: TCF-4, TCF4
Protein Interaction Partner: UBC, FBLN1, UBE2I, PSMA3, MAD2L2, ZBTB33, DAXX, CTNNB1, ELAVL1, PARP1, XRCC5, SUMO2, XRCC6, NR5A1, EP300, CEBPA, CTBP1, DAZAP2, CTNNBIP1, JUP, CSNK2A2, CSNK2A1, PSEN1, NLK, RAC1,
Protein Size: 596

Poids moléculaire: 65 kDa

ID gène: 6934

NCBI Accession: NM_030756, NP_110383

UniProt: Q6FHW4

Pathways: Signalisation WNT, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Regulation of Hormone Metabolic Process, Carbohydrate Homeostasis, Stem Cell Maintenance, Protein targeting to Nucleus