Claudin 19 anticorps (C-Term)

N° du produit ABIN2778043

Cet anticorps anti-Claudin 19 Polyclonal Lapin (ABIN2778043) détecte spécifiquement Claudin 19 dans WB. L’anticorps est réactif avec des échantillons de Humain, Rat, Souris, Boeuf (Vache), Chien, Cobaye, Porc, Lapin et Cheval.

Aperçu rapide pour Claudin 19 anticorps (C-Term) (ABIN2778043)

Antigène: Claudin 19 (CLDN19)

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Cobaye, Porc, Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Claudin 19 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Claudin 19 anticorps

Épitope: C-Term

Fonction: CLDN19 Antibody - C-terminal region

Séquence: AVLGGSFLCC TCPEPERPNS SPQPYRPGPS AAAREPVVKL PASAKGPLGV

Homologie: Cow: 86%, Dog: 100%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against CLDN19. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human CLDN19

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP33619-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Claudin 19

Antigène: Claudin 19 (CLDN19)

Autre désignation: CLDN19

Sujet:

Background Information: CLDN19 belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene Name: Claudin 19

Alternative Symbols: HOMG5

Protein Name: Claudin-19

Poids moléculaire: 23kDa

ID gène: 149461

NCBI Accession: NP_683763

UniProt: Q8N6F1

Pathways: Cell-Cell Junction Organization, Hepatitis C