TIMELESS anticorps (N-Term)

N° du produit ABIN2778314

Détail du produit anti-TIMELESS anticorps

Antigène: TIMELESS (Timeless Homolog (TIMELESS))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Mouton, Cobaye, Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TIMELESS est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: IGERDLIFHK GLHNLRNYSS DLGKQPKKVP KRRQAARELS IQRRSALNVR

Homologie: Cow: 92%, Dog: 85%, Guinea Pig: 77%, Horse: 85%, Human: 100%, Mouse: 85%, Pig: 85%, Rabbit: 77%, Rat: 85%, Sheep: 77%

Attributs du produit: This is a rabbit polyclonal antibody against TIMELESS. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human TIMELESS

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1208 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TIMELESS

Antigène: TIMELESS (Timeless Homolog (TIMELESS))

Autre désignation: TIMELESS (TIMELESS Produits)

Synonymes: anticorps TIM, anticorps TIM1, anticorps hTIM, anticorps C77407, anticorps Debt69, anticorps tim, anticorps CG3234, anticorps Dmel\\CG3234, anticorps Ritsu, anticorps Tim, anticorps dTIM, anticorps dTim, anticorps dtim, anticorps mel_tim, anticorps rit, anticorps tim1, anticorps XTimeless1, anticorps timeless, anticorps timelessb, anticorps TIMELESS, anticorps MXC20.14, anticorps MXC20_14, anticorps htim, anticorps im:6903167, anticorps wu:fa95g04, anticorps wu:fd23d07, anticorps timeless circadian regulator, anticorps timeless circadian clock 1, anticorps timeless, anticorps timeless circadian clock, anticorps timeless circadian clock S homeolog, anticorps timeless family protein, anticorps TIMELESS, anticorps Timeless, anticorps tim, anticorps timeless.S, anticorps Tim, anticorps ATIM, anticorps timeless, anticorps LOC100328917

Sujet: The human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.
Alias Symbols: TIM, TIM1, hTIM
Protein Interaction Partner: UBC, TUT1, TF, XRCC1, FKBP3, SP1, SUMO2, Tipin, Timeless, ZSCAN1, PCBD1, CRY1, PER2, PER1, CLSPN, PCNA, per, Clock, ATRIP, CRY2, CHEK1,
Protein Size: 1208

Poids moléculaire: 139 kDa

ID gène: 8914

NCBI Accession: NM_003920, NP_003911

UniProt: Q9UNS1

Pathways: Protein targeting to Nucleus, Photoperiodism