HDAC4 anticorps (Middle Region)

N° du produit ABIN2778342

L’anticorps Lapin Polyclonal anti-HDAC4 a été validé pour WB. Il convient pour détecter HDAC4 dans des échantillons de Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye et Lapin.

Aperçu rapide pour HDAC4 anticorps (Middle Region) (ABIN2778342)

Antigène: HDAC4 (Histone Deacetylase 4 (HDAC4))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HDAC4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-HDAC4 anticorps

Épitope: Middle Region

Séquence: YLDRLPGQKE AHAQAGVQVK QEPIESDEEE AEPPREVEPG QRQPSEQELL

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against HDAC4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human HDAC4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1084 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur HDAC4

Antigène: HDAC4 (Histone Deacetylase 4 (HDAC4))

Autre désignation: HDAC4

Sujet: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC4 belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HA6116, HD4, HDAC-A, HDACA, KIAA0288, AHO3, BDMR, HDAC-4
Protein Interaction Partner: UBC, TP53BP1, KRT31, MTUS2, KDM5B, HDAC5, NCOR2, PNMA1, KRT38, YWHAG, KRT40, CCDC136, RINT1, ANKRA2, EFEMP2, LDOC1, GSK3B, GOLGA2, CDR2, BCL6, YWHAQ, YWHAB, YWHAE, SIRT1, UBE2I, TBL1XR1, HDAC4, NCOR1, YWHAZ, YWHAH, SFN, MIF4GD, ZBTB7B, APP, ATF3, JDP2, Bt
Protein Size: 1084

Poids moléculaire: 119 kDa

ID gène: 9759

NCBI Accession: NM_006037, NP_006028

UniProt: P56524

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process