HNRNPM anticorps (N-Term)

N° du produit ABIN2778962

Cet anticorps Lapin Polyclonal détecte spécifiquement HNRNPM dans WB. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Porc, Chien, Cheval, Lapin et Cobaye et a été mentionné dans 2+ publications.

Aperçu rapide pour HNRNPM anticorps (N-Term) (ABIN2778962)

Antigène: HNRNPM (Heterogeneous Nuclear Ribonucleoprotein M (HNRNPM))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Porc, Chien, Cheval, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HNRNPM est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-HNRNPM anticorps

Épitope: N-Term

Séquence: ATEIKMEEES GAPGVPSGNG APGPKGEGER PAQNEKRKEK NIKRGGNRFE

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 92%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against HNRPM. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human HNRPM

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 691 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-HNRNPM (ABIN2778962)

Huelga, Vu, Arnold, Liang, Liu, Yan, Donohue, Shiue, Hoon, Brenner, Ares, Yeo: "Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins." dans: Cell reports, Vol. 1, Issue 2, pp. 167-78, (2012) (PubMed).

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." dans: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Détails sur HNRNPM

Antigène: HNRNPM (Heterogeneous Nuclear Ribonucleoprotein M (HNRNPM))

Autre désignation: HNRPM

Sujet: HNRPM belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. HNRPM has three repeats of quasi-RRM domains that bind to RNAs. HNRPM also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules.This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Multiple alternatively spliced transcript variants are known for this gene but only two transcripts has been isolated.
Alias Symbols: DKFZp547H118, HNRNPM, HNRNPM4, HNRPM4, HTGR1, NAGR1, CEAR, HNRPM, hnRNP M
Protein Interaction Partner: UBC, TP53, AKAP9, TEKT4, GMCL1P1, LMO2, HNRNPF, SUMO2, SUMO3, CEP250, MDM2, HAUS1, CDC37, IVNS1ABP, STAU1, SUMO1, RPA3, RPA2, RPA1, EED, rev, RTCB, RPL26L1, RFC4, PSMB8, NMT1, MRE11A, FLII, IGF2BP3, EIF2B2, EIF2B3, RPL27, RPL19, DHX9, DDX1, ABCF1, PARK2,
Protein Size: 691

Poids moléculaire: 73 kDa

ID gène: 4670

NCBI Accession: NM_031203, NP_112480

UniProt: P52272