NXF1 anticorps (N-Term)

N° du produit ABIN2778976

Cet anticorps anti-NXF1 est un anticorps Lapin Polyclonal détectant NXF1 dans WB et IHC. Adapté pour Humain, Souris, Rat, Chien, Cobaye, Boeuf (Vache), Lapin et Cheval.

Aperçu rapide pour NXF1 anticorps (N-Term) (ABIN2778976)

Antigène: NXF1 (Nuclear RNA Export Factor 1 (NXF1))

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Boeuf (Vache), Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NXF1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-NXF1 anticorps

Épitope: N-Term

Séquence: RPNRRGDTWH DRDRIHVTVR RDRAPPERGG AGTSQDGTSK NWFKITIPYG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against NXF1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human NXF1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 619 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur NXF1

Antigène: NXF1 (Nuclear RNA Export Factor 1 (NXF1))

Autre désignation: NXF1

Sujet: NXF1 is one member of a family of nuclear RNA export factor. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. NXF1 shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. NXF1 overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.
Alias Symbols: DKFZp667O0311, MEX67, TAP
Protein Interaction Partner: KRT40, TIFA, GFAP, LDOC1, NUP62, MID2, TP53BP2, DVL3, SUMO2, UBC, SUZ12, EED, BMI1, TARDBP, NXT1, NUP98, RANBP2, ESRRA, KCTD5, TRA2A, SGTA, TRA2B, SRSF1, RAD51, ZBED2, CSNK2A1, EIF2A, ILF3, HNRNPC, HNRNPK, DHX15, DHX9, DDB1, DDX19A, LUC7L3, HP1BP3, RBMX,
Protein Size: 619

Poids moléculaire: 68 kDa

ID gène: 10482

NCBI Accession: NM_006362, NP_006353

UniProt: Q9UBU9