BCL2L1 anticorps (N-Term)

N° du produit ABIN2779336

Cet anticorps Lapin Polyclonal détecte spécifiquement BCL2L1 dans WB. Il présente une réactivité avec des échantillons de Humain, Rat, Souris, Porc, Chien, Boeuf (Vache), Mouton, Lapin, Cheval et Cobaye.

Aperçu rapide pour BCL2L1 anticorps (N-Term) (ABIN2779336)

Antigène: BCL2L1 (BCL2-Like 1 (BCL2L1))

Reactivité: Humain, Rat, Souris, Porc, Chien, Boeuf (Vache), Mouton, Lapin, Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCL2L1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-BCL2L1 anticorps

Épitope: N-Term

Fonction: BCL2L1 Antibody - N-terminal region

Séquence: SNRELVVDFL SYKLSQKGYS WSQFSDVEEN RTEAPEGTES EMETPSAING

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 100%, Rat: 93%, Sheep: 100%

Attributs du produit: This is a rabbit polyclonal antibody against BCL2L1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human BCL2L1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8095471

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur BCL2L1

Antigène: BCL2L1 (BCL2-Like 1 (BCL2L1))

Autre désignation: BCL2L1

Sujet:

Background Information: BCL2L1 encodes a protein which belongs to the BCL-2 protein family. The proteins encoded by BCL2L1 are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis.The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

Gene Name: BCL2-like 1

Alternative Symbols: BCLX, BCL2L, Bcl-X, PPP1R52, BCL-XL/S

Protein Name: Bcl-2-like protein 1

Poids moléculaire: 26kDa

ID gène: 598

NCBI Accession: NP_612815

UniProt: Q07817

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling