DVL1 anticorps (C-Term)

N° du produit ABIN2779457

Cet anticorps anti-DVL1 Polyclonal Lapin (ABIN2779457) détecte spécifiquement DVL1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Porc, Boeuf (Vache), Chien, Cobaye, Cheval et Saccharomyces cerevisiae.

Aperçu rapide pour DVL1 anticorps (C-Term) (ABIN2779457)

Antigène: DVL1 (Dishevelled Segment Polarity Protein 1 (DVL1))

Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Chien, Cobaye, Cheval, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DVL1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-DVL1 anticorps

Épitope: C-Term

Fonction: DVL1 Antibody - C-terminal region

Séquence: AAGAGGSGSE SDHTAPSGVG SSWRERPAGQ LSRGSSPRSQ ASATAPGLPP

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rat: 86%, Yeast: 85%

Attributs du produit: This is a rabbit polyclonal antibody against DVL1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human DVL1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP32101-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur DVL1

Antigène: DVL1 (Dishevelled Segment Polarity Protein 1 (DVL1))

Autre désignation: DVL1

Sujet:

Background Information: DVL1 is a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 gene is a candidate for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1 gene. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.

Gene Name: Dishevelled, dsh homolog 1 (Drosophila)

Alternative Symbols: DVL, DRS2, DVL1L1, DVL1P1

Protein Name: Segment polarity protein dishevelled homolog DVL-1

Poids moléculaire: 73kDa

ID gène: 1855

NCBI Accession: NP_004412

UniProt: O14640

Pathways: Signalisation WNT, Synaptic Membrane, Skeletal Muscle Fiber Development