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EPAS1 anticorps (Middle Region)

EPAS1 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval, Lapin, Chien, Cobaye, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2779523
  • Antigène Voir toutes EPAS1 Anticorps
    EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
    Épitope
    • 16
    • 11
    • 9
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 92
    • 48
    • 42
    • 18
    • 17
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Boeuf (Vache), Cheval, Lapin, Chien, Cobaye, Poisson zèbre (Danio rerio)
    Hôte
    • 100
    • 11
    • 1
    • 1
    Lapin
    Clonalité
    • 92
    • 21
    Polyclonal
    Conjugué
    • 57
    • 14
    • 7
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp EPAS1 est non-conjugé
    Application
    • 92
    • 47
    • 32
    • 24
    • 15
    • 14
    • 14
    • 13
    • 13
    • 12
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    ESLFKPHLMA MNSIFDSSGK GAVSEKSNFL FTKLKEEPEE LAQLAPTPGD
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
    Attributs du produit
    This is a rabbit polyclonal antibody against EPAS1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human EPAS1
    Top Product
    Discover our top product EPAS1 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 870 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
    Autre désignation
    EPAS1 (EPAS1 Produits)
    Synonymes
    anticorps EPAS1, anticorps ECYT4, anticorps HIF2A, anticorps HLF, anticorps MOP2, anticorps PASD2, anticorps bHLHe73, anticorps HIF-2alpha, anticorps HRF, anticorps Hif2a, anticorps bhlhe73, anticorps ecyt4, anticorps hif2, anticorps hif2a, anticorps hif2alpha, anticorps hlf, anticorps mop2, anticorps pasd2, anticorps EPAS, anticorps EPAS-1, anticorps endothelial PAS domain protein 1, anticorps endothelial PAS domain protein 1 L homeolog, anticorps EPAS1, anticorps epas1, anticorps Epas1, anticorps epas1.L
    Sujet
    EPAS1 is a transcription factor involved in the induction of oxygen regulated genes. EPAS1 binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. EPAS1 regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. EPAS1 may also play a role in the formation of the endothelium that gives rise to the blood brain barrier. EPAS1 is a potent activator of the Tie-2 tyrosine kinase expression. The activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction of EPAS1 with redox regulatory protein APEX seems to activate CTAD.
    Alias Symbols: HIF2A, HLF, MOP2, PASD2, ECYT4, bHLHe73
    Protein Interaction Partner: MAP1LC3A, SQSTM1, LAMP1, BATF2, BATF3, BATF, DDIT3, DBP, NDN, JUN, EPAS1, NPM1, BBS4, BBS2, BBS1, Arnt, VHL, STAT5A, SMAD3, EWSR1, MED11, MED8, EGLN3, PSMD1, PSMB1, MED1, PHB, MITF, HIF1A, EP300, EMD, CTNNB1, CREBBP, EGLN2, DPY30, MED10, MED25, ARID1B, WR
    Protein Size: 870
    Poids moléculaire
    90 kDa
    ID gène
    2034
    NCBI Accession
    NM_001430, NP_001421
    UniProt
    Q99814
    Pathways
    Signaling Events mediated by VEGFR1 and VEGFR2, L'effet Warburg
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