SIRT3 anticorps (C-Term)

N° du produit ABIN2779610

Cet anticorps Lapin Polyclonal détecte spécifiquement SIRT3 dans WB et IHC. Il présente une réactivité envers Humain, Souris, Rat, Chien, Lapin, Cobaye, Cheval et Boeuf (Vache) et a été mentionné dans 3+ publications.

Aperçu rapide pour SIRT3 anticorps (C-Term) (ABIN2779610)

Antigène: SIRT3 (Sirtuin 3 (SIRT3))

Reactivité: Humain, Souris, Rat, Chien, Lapin, Cobaye, Cheval, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIRT3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-SIRT3 anticorps

Épitope: C-Term

Séquence: VGPLAWHPRS RDVAQLGDVV HGVESLVELL GWTEEMRDLV QRETGKLDGP

Homologie: Cow: 100%, Dog: 79%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against SIRT3. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human SIRT3

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 257 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SIRT3 (ABIN2779610)

Vidimar, Gius, Chakravarti, Bulun, Wei, Kim: "Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas." dans: Science advances, Vol. 2, Issue 11, pp. e1601132, (2016) (PubMed).

Marfè, Tafani, Fiorito, Pagnini, Iovane, De Martino: "Involvement of FOXO transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type II-induced apoptosis." dans: PLoS ONE, Vol. 6, Issue 11, pp. e27313, (2011) (PubMed).

Lanza, Short, Short, Raghavakaimal, Basu, Joyner, McConnell, Nair: "Endurance exercise as a countermeasure for aging." dans: Diabetes, Vol. 57, Issue 11, pp. 2933-42, (2008) (PubMed).

Détails sur SIRT3

Antigène: SIRT3 (Sirtuin 3 (SIRT3))

Autre désignation: SIRT3

Sujet: The SIRT3 gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT3 encodes a protein that is included in class I of the sirtuin family.
Alias Symbols: SIR2L3
Protein Interaction Partner: SIRT5, SKP2, UBC, HSPD1, CMYA5, PGAP1, RIF1, NCAPD2, HERC2, TTF2, UQCRH, UGDH, HSP90B1, SNTB1, SBF1, HSPA9, HSPA5, HSPA4, HSPA1L, GRN, ATP5B, ATP5A1, SIRT4, tat, XRCC6, FOXO3, DNM1L, PEX5,
Protein Size: 257

Poids moléculaire: 28 kDa

ID gène: 23410

NCBI Accession: NM_001017524, NP_001017524

UniProt: Q9NTG7