APEX1 anticorps (N-Term)

N° du produit ABIN2779778

Détail du produit anti-APEX1 anticorps

Antigène: APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye, Chévre

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APEX1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: KGLDWVKEEA PDILCLQETK CSENKLPAEL QELPGLSHQY WSAPSDKEGY

Homologie: Cow: 92%, Dog: 92%, Goat: 83%, Guinea Pig: 85%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against APEX1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human APEX1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 318 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur APEX1

Antigène: APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

Autre désignation: APEX1 (APEX1 Produits)

Synonymes: anticorps apex1, anticorps MGC76280, anticorps MGC79645, anticorps MGC78928, anticorps APE, anticorps APE1, anticorps APEN, anticorps APEX, anticorps APX, anticorps HAP1, anticorps REF1, anticorps Apex, anticorps REF-1, anticorps BAP1, anticorps apex1a, anticorps hm:zehn1532, anticorps wu:fc13d11, anticorps zgc:66204, anticorps Ref-1, anticorps apurinic/apyrimidinic endodeoxyribonuclease 1, anticorps APEX nuclease (multifunctional DNA repair enzyme) 1, anticorps APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog, anticorps DNA-(apurinic or apyrimidinic site) lyase, anticorps apurinic/apyrimidinic endonuclease 1, anticorps APEX1, anticorps apex1, anticorps apex1.L, anticorps CNG03640, anticorps CNH01280, anticorps nth, anticorps Spirs_4119, anticorps Palpr_0103, anticorps Apex1

Sujet: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells.
Alias Symbols: APE, APX, APE1, APEN, APEX, HAP1, REF1
Protein Interaction Partner: GADD45A, UBC, RPA3, RPA2, RPA1, rev, CCDC124, RIC8A, PABPC1, TWF2, XPOT, HNRNPUL1, ARIH2, PAPSS2, NAE1, PSMG1, TXNRD1, TXN, TCEB1, LGALS1, HNRNPK, CAPNS1, SRPK2, SRPK1, MUTYH, HMGA1, HMGA2, GZMK, GZMA, YBX1, EP300, ASCL2, STAT3, SNRPD1, SFPQ, APP, UBE2I,
Protein Size: 318

Poids moléculaire: 35 kDa

ID gène: 328

NCBI Accession: NM_080648, NP_542379

UniProt: P27695

Pathways: Réparation de l'ADN, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus