SMAD6 anticorps (C-Term)

N° du produit ABIN2779803

Cet anticorps anti-SMAD6 est un anticorps Lapin Polyclonal détectant SMAD6 dans WB. Adapté pour Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio) et Lapin.

Aperçu rapide pour SMAD6 anticorps (C-Term) (ABIN2779803)

Antigène: SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio), Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMAD6 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SMAD6 anticorps

Épitope: C-Term

Séquence: PDGVWAYNRG EHPIFVNSPT LDAPGGRALV VRKVPPGYSI KVFDFERSGL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against Smad6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of MOUSE Smad6

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SMAD6

Antigène: SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))

Autre désignation: Smad6

Sujet: Smad6 binds to regulatory elements in target promoter regions. It may block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. It acts as a mediator of TGF-beta and BMP antiflammatory activity. It suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes.
Protein Interaction Partner: Smurf1, Tbx6, Bmpr2, Bmpr1a, Acvr1, Runx2, tob1a, Axin1, SMURF2, BMPR1B,
Protein Size: 459

Poids moléculaire: 54 kDa

ID gène: 17130

UniProt: O35182

Pathways: Chromatin Binding