G3BP1 anticorps (N-Term)

N° du produit ABIN2780221

Cet anticorps anti-G3BP1 est un anticorps Lapin Polyclonal détectant G3BP1 dans WB. Adapté pour Humain, Souris, Rat, Chien, Cheval, Cobaye, Boeuf (Vache), Lapin et Porc. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour G3BP1 anticorps (N-Term) (ABIN2780221)

Antigène: G3BP1 (GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1))

Reactivité: Humain, Souris, Rat, Chien, Cheval, Cobaye, Boeuf (Vache), Lapin, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp G3BP1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-G3BP1 anticorps

Épitope: N-Term

Séquence: EVFGGFVTEP QEESEEEVEE PEERQQTPEV VPDDSGTFYD QAVVSNDMEE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against G3BP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human G3BP

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 466 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-G3BP1 (ABIN2780221)

Lind, Svedin, Domsgen, Kapell, Laitinen, Moll, Flodström-Tullberg: "Coxsackievirus counters the host innate immune response by blocking type III interferon expression." dans: The Journal of general virology, Vol. 97, Issue 6, pp. 1-12, (2016) (PubMed).

Schulte, Liu, Panas, Thaa, Dickson, Götte, Achour, McInerney: "Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication." dans: Open biology, Vol. 6, Issue 7, (2016) (PubMed).

Détails sur G3BP1

Antigène: G3BP1 (GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1))

Autre désignation: G3BP

Sujet: G3BP is one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Alias Symbols: G3BP, HDH-VIII
Protein Interaction Partner: UBC, USP10, FXR2, MDM2, RNF2, BMI1, RPS27L, EDC4, RPL35, RPL14, EIF2B3, EIF3C, PTBP1, PIN1, PA2G4, YBX1, HNRNPU, FAU, SH3RF2, TARDBP, FBXO25, RIOK2, SND1, VCAM1, env, ITGA4, IL7R, FN1, EPHA8, DTX1, PABPC1, PAXIP1, ESR1, APP, NOLC1, TPM4, LCK, CSK, KCND3,
Protein Size: 466

Poids moléculaire: 51 kDa

ID gène: 10146

NCBI Accession: NM_005754, NP_005745

UniProt: Q13283

Pathways: SARS-CoV-2 Protein Interactome