RUNX2 anticorps (N-Term)

N° du produit ABIN2780588

Cité dans 2 publications. Cet anticorps anti-RUNX2 Polyclonal Lapin (ABIN2780588) détecte spécifiquement RUNX2 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Cobaye, Boeuf (Vache), Cheval et Poisson zèbre (Danio rerio).

Aperçu rapide pour RUNX2 anticorps (N-Term) (ABIN2780588)

Antigène: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Reactivité: Humain, Souris, Rat, Cobaye, Boeuf (Vache), Cheval, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RUNX2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RUNX2 anticorps

Épitope: N-Term

Fonction: RUNX2 Antibody - N-terminal region

Séquence: MRIPVDPSTS RRFSPPSSSL QPGKMSDVSP VVAAQQQQQQ QQQQQQQQQQ

Homologie: Cow: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against RUNX2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human RUNX2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP38452-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-RUNX2 (ABIN2780588)

Li, Fan, Chen, Yang, Su, Bi: "Construction of adipose scaffold for bone repair with gene engineering bone cells." dans: Experimental biology and medicine (Maywood, N.J.), Vol. 238, Issue 12, pp. 1350-4, (2013) (PubMed).

Lee, Lee, Ryoo, Park, Park, Bae, Cho, Park: "The odontogenic ameloblast-associated protein (ODAM) cooperates with RUNX2 and modulates enamel mineralization via regulation of MMP-20." dans: Journal of cellular biochemistry, Vol. 111, Issue 3, pp. 755-67, (2010) (PubMed).

Détails sur RUNX2

Antigène: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Autre désignation: RUNX2

Sujet:

Background Information: RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis, acting as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants, encoding different protein isoforms, result from alternate promoter use as well as alternate splicing.

Gene Name: Runt-related transcription factor 2

Alternative Symbols: CCD, AML3, CCD1, CLCD, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2aA, CBF-alpha-1

Protein Name: Runt-related transcription factor 2

Poids moléculaire: 55kDa

ID gène: 860

NCBI Accession: NP_004339

UniProt: Q13950