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HMGN1 anticorps (Middle Region)

HMGN1 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Porc, Chien, Cheval, Lapin, Cobaye WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2780630
  • Antigène Voir toutes HMGN1 Anticorps
    HMGN1 (High Mobility Group Nucleosome Binding Domain 1 (HMGN1))
    Épitope
    • 18
    • 15
    • 15
    • 14
    • 8
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 67
    • 17
    • 13
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Boeuf (Vache), Porc, Chien, Cheval, Lapin, Cobaye
    Hôte
    • 69
    • 1
    Lapin
    Clonalité
    • 69
    • 1
    Polyclonal
    Conjugué
    • 32
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp HMGN1 est non-conjugé
    Application
    • 46
    • 29
    • 28
    • 28
    • 26
    • 14
    • 11
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    QTKGKRGAKG KQAEVANQET KEDLPAENGE TKTEESPASD EAGEKEAKSD
    Homologie
    Cow: 93%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 93%, Rat: 79%
    Attributs du produit
    This is a rabbit polyclonal antibody against HMGN1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human HMGN1
    Top Product
    Discover our top product HMGN1 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 100 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Lane, Chapuy, Lin, Tivey, Li, Townsend, van Bodegom, Day, Wu, Liu, Yoda, Alexe, Schinzel, Sullivan, Malinge, Taylor, Stegmaier, Jaffe, Bustin, te Kronnie, Izraeli, Harris, Stevenson, Neuberg et al.: "Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. ..." dans: Nature genetics, Vol. 46, Issue 6, pp. 618-23, (2014) (PubMed).

  • Antigène
    HMGN1 (High Mobility Group Nucleosome Binding Domain 1 (HMGN1))
    Autre désignation
    HMGN1 (HMGN1 Produits)
    Synonymes
    anticorps HMG14, anticorps hmg14, anticorps hmgn1, anticorps hmgn1b, anticorps HMG-14, anticorps Hmg14, anticorps high mobility group nucleosome binding domain 1, anticorps high mobility group nucleosome binding domain 1 S homeolog, anticorps high mobility group nucleosomal binding domain 1, anticorps non-histone chromosomal protein HMG-14, anticorps HMGN1, anticorps hmgn1.S, anticorps hmgn1, anticorps Hmgn1, anticorps LOC785479
    Sujet
    Chromosomal protein HMG14 (HMGN1) and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: FLJ27265, FLJ31471, HMG14, MGC104230, MGC117425
    Protein Interaction Partner: UBC, RPS6KA3, PRKCA, PRKACG, SLC38A3, PPP1CC, LIG4, PPIP5K1, TERF2, SPP1, POLR2A, ERCC8, HDGF, EP300, BTG2, ERCC6, NFE2, RPS6KA5, RPS6KA4, PRKACA, YWHAZ, HMGN1, HMGN2, IRF2,
    Protein Size: 100
    Poids moléculaire
    11 kDa
    ID gène
    3150
    NCBI Accession
    NM_004965, NP_004956
    UniProt
    Q6NSG7
    Pathways
    Chromatin Binding
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