SMAD4 anticorps (C-Term)

N° du produit ABIN2780674

L’anticorps anti-SMAD4 Polyclonal Lapin est utilisé pour la détection de SMAD4 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Poisson zèbre (Danio rerio), Chien, Chévre, Cobaye, Cheval, Lapin et Mouton. Il a été validé pour WB.

Aperçu rapide pour SMAD4 anticorps (C-Term) (ABIN2780674)

Antigène: SMAD4 (SMAD Family Member 4 (SMAD4))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Poisson zèbre (Danio rerio), Chien, Chévre, Cobaye, Cheval, Lapin, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMAD4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SMAD4 anticorps

Épitope: C-Term

Fonction: SMAD4 Antibody - C-terminal region

Séquence: AAAGIGVDDL RRLCILRMSF VKGWGPDYPR QSIKETPCWI EIHLHRALQL

Homologie: Cow: 100%, Dog: 100%, Goat: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against Smad4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of mouse SMAD4

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP38606-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur SMAD4

Antigène: SMAD4 (SMAD Family Member 4 (SMAD4))

Autre désignation: SMAD4

Sujet:

Background Information: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

Gene Name: SMAD family member 4

Alternative Symbols: JIP, DPC4, MADH4, MYHRS

Protein Name: mothers against decapentaplegic homolog 4

Poids moléculaire: 50kDa

ID gène: 4089

NCBI Accession: NP_005350

UniProt: Q13485

Pathways: Cycle Cellulaire, Chromatin Binding, Autophagy