TARDBP anticorps (N-Term)

N° du produit ABIN2780848

Il existe 1 publication pour ce produit. L’anticorps anti-TARDBP Polyclonal Lapin est utilisé pour la détection de TARDBP dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval et Cobaye. Il a été validé pour WB et IHC.

Aperçu rapide pour TARDBP anticorps (N-Term) (ABIN2780848)

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TARDBP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-TARDBP anticorps

Épitope: N-Term

Fonction: TARDBP Antibody - N-terminal region

Séquence: MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against TARDBP. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human TARDBP

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP38941-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-TARDBP (ABIN2780848)

Estes, Boehringer, Zwick, Tang, Grigsby, Zarnescu: "Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS." dans: Human molecular genetics, Vol. 20, Issue 12, pp. 2308-21, (2011) (PubMed).

Détails sur TARDBP

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Autre désignation: TARDBP

Sujet:

Background Information: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. TARDBP is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription.HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Gene Name: TAR DNA binding protein

Alternative Symbols: ALS10, TDP-43

Protein Name: TAR DNA-binding protein 43

Poids moléculaire: 45kDa

ID gène: 23435

NCBI Accession: NP_031401

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion