SETDB1 anticorps (N-Term)

N° du produit ABIN2780883

Détail du produit anti-SETDB1 anticorps

Antigène: SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

Épitope: N-Term

Reactivité: Humain, Rat, Chien, Cobaye, Cheval, Lapin, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SETDB1 est non-conjugé

Application: Western Blotting (WB)

Séquence: PGCIGLDAAT ATVESEEIAE LQQAVVEELG ISMEELRHFI DEELEKMDCV

Homologie: Cow: 92%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Rabbit: 85%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against SETDB1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SETDB1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SETDB1

Antigène: SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

Autre désignation: SETDB1 (SETDB1 Produits)

Synonymes: anticorps ESET, anticorps H3-K9-HMTase4, anticorps KG1T, anticorps KMT1E, anticorps TDRD21, anticorps AU022152, anticorps mKIAA0067, anticorps SETDB1, anticorps NV10069, anticorps fc07d03, anticorps si:ch211-81a5.6, anticorps wu:fc07d03, anticorps im:7143091, anticorps wu:fa04a12, anticorps wu:fj80h02, anticorps zgc:152899, anticorps SET domain bifurcated 1, anticorps SET domain, bifurcated 1, anticorps myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11, anticorps histone-lysine N-methyltransferase SETDB1, anticorps SET domain, bifurcated 1a, anticorps SET domain bifurcated 1 L homeolog, anticorps SET domain, bifurcated 1b, anticorps SETDB1, anticorps Setdb1, anticorps MLLT11, anticorps LOC100120014, anticorps LOC100461671, anticorps setdb1a, anticorps setdb1.L, anticorps setdb1b

Sujet: SETDB1 is a histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.
Protein Interaction Partner: MDM2, HSP90AA1, UBC, SKIL, LRIF1, BARD1, APLP1, TCERG1, TRIM28, VIM, SUMO2, PML, CLSTN1, JARID2, tat, MZT2B, FAM118B, MRPL44, LUC7L2, MAP4K5, TSC22D1, TTR, TK1, SMN1, PCYT2, PSME1, GRB7, CDKN1A, CDK4, BID, ANXA7, ZNF274, HIST1H3A, ESCO1, AKT2, AKT1, PPARG
Protein Size: 397

Poids moléculaire: 43 kDa

ID gène: 9869