PIAS1 anticorps (N-Term)

N° du produit ABIN2780997

Cet anticorps anti-PIAS1 Polyclonal Lapin (ABIN2780997) détecte spécifiquement PIAS1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Cheval, Boeuf (Vache), Chien, Lapin, Cobaye et Poisson zèbre (Danio rerio).

Aperçu rapide pour PIAS1 anticorps (N-Term) (ABIN2780997)

Antigène: PIAS1 (Protein Inhibitor of Activated STAT, 1 (PIAS1))

Reactivité: Humain, Souris, Rat, Cheval, Boeuf (Vache), Chien, Lapin, Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIAS1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PIAS1 anticorps

Épitope: N-Term

Fonction: PIAS1 Antibody - N-terminal region

Séquence: MADSAELKQM VMSLRVSELQ VLLGYAGRNK HGRKHELLTK ALHLLKAGCS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PIAS1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PIAS1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP39231-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur PIAS1

Antigène: PIAS1 (Protein Inhibitor of Activated STAT, 1 (PIAS1))

Autre désignation: PIAS1

Sujet:

Background Information: PIAS1 is a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Protein inhibitor of activated STAT, 1

Alternative Symbols: GBP, ZMIZ3, DDXBP1, GU/RH-II

Protein Name: E3 SUMO-protein ligase PIAS1

Poids moléculaire: 72kDa

ID gène: 8554

NCBI Accession: NP_057250

UniProt: O75925

Pathways: Signalistation JAK/STAT, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C