Notch1 anticorps (Middle Region)

N° du produit ABIN2781033

L’anticorps anti-Notch1 Polyclonal Lapin est utilisé pour la détection de Notch1 dans des échantillons de Humain, Souris, Rat, Poisson zèbre (Danio rerio), Boeuf (Vache), Chien, Cobaye et Cheval. Il a été validé pour WB.

Aperçu rapide pour Notch1 anticorps (Middle Region) (ABIN2781033)

Antigène: Notch1 (NOTCH1) (Notch 1 (NOTCH1))

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Boeuf (Vache), Chien, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Notch1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Notch1 anticorps

Épitope: Middle Region

Fonction: NOTCH1 Antibody - middle region

Séquence: EHPFLTPSPE SPDQWSSSSP HSNVSDWSEG VSSPPTSMQS QIARIPEAFK

Specificité: Antibody recognizes 88 kDa for Notch1 intracellular domain.

Homologie: Cow: 79%, Dog: 79%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 79%, Rat: 93%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against NOTCH1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human NOTCH1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP39295-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Notch1

Antigène: Notch1 (NOTCH1) (Notch 1 (NOTCH1))

Autre désignation: NOTCH1

Sujet:

Background Information: NOTCH1 is a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Notch 1

Alternative Symbols: hN1, AOS5, TAN1, AOVD1

Protein Name: Neurogenic locus notch homolog protein 1

Poids moléculaire: 273 kDa

ID gène: 4851

NCBI Accession: NP_060087

UniProt: P46531

Pathways: Signalisation Notch, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development