KDM6A anticorps (Middle Region)

N° du produit ABIN2781142

Détail du produit anti-KDM6A anticorps

Antigène: KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Poisson zèbre (Danio rerio), Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDM6A est non-conjugé

Application: Western Blotting (WB)

Séquence: KTYIVHCQDC ARKTSGNLEN FVVLEQYKME DLMQVYDQFT LAPPLPSASS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against UTX. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human UTX

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1401 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur KDM6A

Antigène: KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Autre désignation: UTX (KDM6A Produits)

Synonymes: anticorps KABUK2, anticorps UTX, anticorps bA386N14.2, anticorps Utx, anticorps si:ch211-222m21.1, anticorps utx, anticorps kdm6a, anticorps tutx, anticorps uty, anticorps xtutx, anticorps lysine demethylase 6A, anticorps lysine-specific demethylase 6A, anticorps lysine (K)-specific demethylase 6A, anticorps lysine demethylase 6A S homeolog, anticorps KDM6A, anticorps LOC100539898, anticorps Kdm6a, anticorps kdm6a, anticorps kdm6a.S

Sujet: UTX is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. UTX plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitent with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.
Alias Symbols: DKFZp686A03225, MGC141941, bA386N14.2, UTX, KABUK2
Protein Interaction Partner: KMT2D, WDR5, ASH2L, RBBP5, SMAD9, HIST2H3C, SRF, SMARCA4, GATA4, NKX2-5, TBX5, UBC, HIST1H3A, WDR82, PAXIP1, NCOA6, TLE1, PROSER1, KMT2C, N4BP2, PPP6R3, ZNF281, HIST3H3,
Protein Size: 1401

Poids moléculaire: 154 kDa

ID gène: 7403

NCBI Accession: NM_021140, NP_066963

UniProt: O15550

Pathways: Tube Formation, L'effet Warburg