TRIM11 anticorps (C-Term)

N° du produit ABIN2781254

L’anticorps anti-TRIM11 Polyclonal Lapin est utilisé pour la détection de TRIM11 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Cheval, Chien, Cobaye et Lapin. Il a été validé pour WB.

Aperçu rapide pour TRIM11 anticorps (C-Term) (ABIN2781254)

Antigène: TRIM11 (Tripartite Motif Containing 11 (TRIM11))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval, Chien, Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM11 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TRIM11 anticorps

Épitope: C-Term

Fonction: Trim11 Antibody - C-terminal region

Séquence: GSFYNSNEPA FSPLRDPPKR VGIFLDYEAG HLSFYSATDG SLLFIFPETL

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against Trim11. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide corresponding to a region of Mouse

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP43411-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur TRIM11

Antigène: TRIM11 (Tripartite Motif Containing 11 (TRIM11))

Autre désignation: Trim11

Sujet:

Background Information: Trim11 is an E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. It may also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. It may contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. It mediates MED15 ubiquitination leading to proteasomal degradation. Trim11 may contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. Trim11 may regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

Gene Name: Tripartite motif-containing 11

Alternative Symbols: -

Protein Name: E3 ubiquitin-protein ligase TRIM11

Poids moléculaire: 52kDa

ID gène: 94091

NCBI Accession: NP_444398

UniProt: Q99PQ2