CBP anticorps (N-Term)

N° du produit ABIN2781491

Cet anticorps anti-CBP est un anticorps Lapin Polyclonal détectant CBP dans WB et IHC. Adapté pour Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cobaye et Cheval.

Aperçu rapide pour CBP anticorps (N-Term) (ABIN2781491)

Antigène: CBP (CREBBP) (CREB Binding Protein (CREBBP))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-CBP anticorps

Épitope: N-Term

Séquence: TPAASQALNP QAQKQVGLAT SSPATSQTGP GICMNANFNQ THPGLLNSNS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CREBBP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CREBBP

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 2404 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CBP

Antigène: CBP (CREBBP) (CREB Binding Protein (CREBBP))

Autre désignation: CREBBP

Sujet: CREBBP is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. CREBBP has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain.
Alias Symbols: CBP, KAT3A, RSTS, RTS
Protein Interaction Partner: SUMO1, UBE2I, UBE2D1, TDG, RELA, CREBBP, KLF2, KLF4, WRN, PSME3, COPS2, UBC, BMI1, EID1, ATF4, DYRK1B, DYRK1A, ATF2, CREB1, CDK2, JUN, PPARG, IRF3, HNF4A, KLF1, vIRF-3, AR, vIRF-1, CNTN2, SMAD3, SMAD2, LDLR, STAT1, K8, MTDH, MEIS1, TLR2, EPAS1, MYBL1, LIG
Protein Size: 2404

Poids moléculaire: 261 kDa

ID gène: 1387

NCBI Accession: NM_001079846, NP_001073315

UniProt: Q4LE28

Pathways: TCR Signaling, Interferon-gamma Pathway, Stem Cell Maintenance, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha