CYBB anticorps (C-Term)

N° du produit ABIN2781794

Cet anticorps Lapin Polyclonal détecte spécifiquement CYBB dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour CYBB anticorps (C-Term) (ABIN2781794)

Antigène: CYBB (Cytochrome B-245, beta Polypeptide (CYBB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYBB est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CYBB anticorps

Épitope: C-Term

Séquence: YGRPNWDNEF KTIASQHPNT RIGVFLCGPE ALAETLSKQS ISNSESGPRG

Homologie: Cow: 79%, Dog: 93%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CYBB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human CY24B

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 570 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CYBB

Antigène: CYBB (Cytochrome B-245, beta Polypeptide (CYBB))

Autre désignation: CYBB

Sujet: Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase, neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
Alias Symbols: CGD, NOX2, IMD34, AMCBX2, GP91-1, GP91PHOX, p91-PHOX, GP91-PHOX,
Protein Interaction Partner: IQGAP1, ACTB, UBC, SUMO1, RAC1, NCF4, NCF2, NCF1, CYBA, ACTG1,
Protein Size: 570

Poids moléculaire: 62 kDa

ID gène: 1536

NCBI Accession: NM_000397, NP_000388

UniProt: P04839