UGT1A1 anticorps (N-Term)

N° du produit ABIN2781804

Détail du produit anti-UGT1A1 anticorps

Antigène: UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UGT1A1 est non-conjugé

Application: Western Blotting (WB)

Séquence: DGSHWLSMLG AIQQLQQRGH EIVVLAPDAS LYIRDGAFYT LKTYPVPFQR

Homologie: Horse: 86%, Human: 100%, Mouse: 79%, Rat: 82%

Attributs du produit: This is a rabbit polyclonal antibody against UGT1A1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human UGT1A1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 533 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur UGT1A1

Antigène: UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1))

Autre désignation: UGT1A1 (UGT1A1 Produits)

Synonymes: anticorps BILIQTL1, anticorps GNT1, anticorps HUG-BR1, anticorps UDPGT, anticorps UDPGT 1-1, anticorps UGT1, anticorps UGT1A, anticorps Gnt1, anticorps UGT1A01, anticorps Udpgt-1a, anticorps UgtBr1, anticorps Udpgt, anticorps Ugt1, anticorps zgc:123097, anticorps UDP glucuronosyltransferase family 1 member A1, anticorps UDP glucuronosyltransferase 1 family, polypeptide A1, anticorps UDP-glucuronosyltransferase 1-1, anticorps UDP-glucuronosyltransferase, anticorps UDP-glucuronosyltransferase 1-6, anticorps UDP glucuronosyltransferase 1 family polypeptide a1, anticorps UGT1A1, anticorps Ugt1a1, anticorps LOC100065342, anticorps LOC100125517, anticorps LOC100229734, anticorps LOC100405984, anticorps LOC100511479, anticorps ugt1a1

Sujet: UGT1A1 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: GNT1, HUG-BR1, UDPGT, UGT1, UGT1A, BILIQTL1, UDPGT 1-1
Protein Interaction Partner: COPZ1, SEC23B, UGDH, B3GALT1,
Protein Size: 533

Poids moléculaire: 57 kDa

ID gène: 54658

NCBI Accession: NM_000463, NP_000454

UniProt: P22309

Pathways: Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha