PARL anticorps (N-Term)

N° du produit ABIN2782038

L’anticorps Lapin Polyclonal anti-PARL a été validé pour WB et IHC. Il convient pour détecter PARL dans des échantillons de Humain, Souris, Rat, Chien, Cheval, Porc, Lapin, Boeuf (Vache) et Cobaye. Il y a 1 publication disponible.

Aperçu rapide pour PARL anticorps (N-Term) (ABIN2782038)

Antigène: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Reactivité: Humain, Souris, Rat, Chien, Cheval, Porc, Lapin, Boeuf (Vache), Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARL est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-PARL anticorps

Épitope: N-Term

Séquence: SLIKPLFFTV GFTGCAFGSA AIWQYESLKS RVQSYFDGIK ADWLDSIRPQ

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%,

Attributs du produit: This is a rabbit polyclonal antibody against PARL. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PARL

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 329 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PARL (ABIN2782038)

Yoshioka, Katsu, Sakata, Okami, Wakai, Kinouchi, Chan: "The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia." dans: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 33, Issue 11, pp. 1658-65, (2013) (PubMed).

Détails sur PARL

Antigène: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Autre désignation: PARL

Sujet: PARL is a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. PARL may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in its gene has been associated with increased risk for type 2 diabetes.This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1
Protein Interaction Partner: UBC, PINK1,
Protein Size: 329

Poids moléculaire: 36 kDa

ID gène: 55486

NCBI Accession: NM_001037639, NP_001032728

Pathways: Autophagy