Indian Hedgehog anticorps (N-Term)

N° du produit ABIN2782160

Détail du produit anti-Indian Hedgehog anticorps

Antigène: Indian Hedgehog (IHH)

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Boeuf (Vache), Chévre, Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Indian Hedgehog est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: AAWGCGPGRV VGSRRRPPRK LVPLAYKQFS PNVPEKTLGA SGRYEGKIAR

Homologie: Cow: 86%, Dog: 86%, Goat: 86%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against IHH. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human IHH

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 411 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Indian Hedgehog (ABIN2782160)

Mirza, Qiao, Tateyama, Miyamoto, Xiuli, Seo: "3?-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species." dans: Journal of bone and mineral metabolism, Vol. 30, Issue 2, pp. 144-53, (2012) (PubMed).

Détails sur Indian Hedgehog

Antigène: Indian Hedgehog (IHH)

Autre désignation: IHH (IHH Produits)

Synonymes: anticorps BDA1, anticorps HHG2, anticorps X-hh, anticorps Xbhh, anticorps bhh, anticorps bhh-a, anticorps IHH, anticorps ehh, anticorps zgc:113262, anticorps indian hedgehog, anticorps Indian hedgehog, anticorps indian hedgehog S homeolog, anticorps Indian hedgehog homolog b, anticorps IHH, anticorps Ihh, anticorps ihh.S, anticorps ihhb

Sujet: IHH is an intercellular signal essential for a variety of patterning events during development. It binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. It is implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones and induces the expression of parathyroid hormone-related protein (PTHRP).
Alias Symbols: BDA1, HHG2
Protein Interaction Partner: RHOD, HHIP, PTCH2, PTCH1,
Protein Size: 411

Poids moléculaire: 45 kDa

ID gène: 3549

NCBI Accession: NM_002181, NP_002172

UniProt: Q14623

Pathways: Signalisation Hedgehog