Patched 2 anticorps (N-Term)

N° du produit ABIN502640

L’anticorps anti-Patched 2 Polyclonal Lapin est utilisé pour la détection de Patched 2 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin et Cobaye. Il a été validé pour WB.

Aperçu rapide pour Patched 2 anticorps (N-Term) (ABIN502640)

Antigène: Patched 2 (PTCH2)

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Patched 2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Patched 2 anticorps

Épitope: N-Term

Fonction: PTCH2 Antibody - N-terminal region

Séquence: LAQEALPENA SQQIHAFSST TLDDILHAFS EVSAARVVGG YLLMLAYACV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against PTCH2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PTCH2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45522-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Patched 2

Antigène: Patched 2 (PTCH2)

Autre désignation: PTCH2

Sujet:

Background Information: PTCH2 is a member of the patched protein family. The patched protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. The gene encoding PTCH2 is shown to be mutated in a medulloblastoma and in a basal cell carcinoma, suggesting that it plays a role in the development of some tumors. This gene encodes a member of the patched gene family. The patched protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. This gene is shown to be mutated in a medulloblastoma and in a basal cell carcinoma, suggesting that it plays a role in the development of some tumors. Alternative transcript variants have been described, but their biological function has not been determined. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-10 AF119569.1 1-10 11-534 AY359016.1 3-526 535-2066 AF087651.1 523-2054 2067-2509 AF119569.1 2067-2509 2510-2520 AF087651.1 2498-2508 2521-2700 AF119569.1 2521-2700 2701-3620 AY358555.1 2689-3608 3621-3624 AF087651.1 3609-3612

Gene Name: Patched 2

Alternative Symbols: PTC2

Protein Name: Protein patched homolog 2

Poids moléculaire: 130kDa

ID gène: 8643

NCBI Accession: NP_003729

UniProt: Q9Y6C5

Pathways: Signalisation Hedgehog