KLKB1 anticorps (Middle Region)

N° du produit ABIN2782312

Cet anticorps Lapin Polyclonal détecte spécifiquement KLKB1 dans WB. Il présente une réactivité envers Humain, Rat, Chien, Cheval et Porc et a été mentionné dans 1 publication.

Aperçu rapide pour KLKB1 anticorps (Middle Region) (ABIN2782312)

Antigène: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Reactivité: Humain, Rat, Chien, Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KLKB1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-KLKB1 anticorps

Épitope: Middle Region

Séquence: VLTAAHCFDG LPLQDVWRIY SGILNLSDIT KDTPFSQIKE IIIHQNYKVS

Homologie: Dog: 86%, Horse: 86%, Human: 100%, Pig: 79%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against KLKB1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human KLKB1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 638 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-KLKB1 (ABIN2782312)

Tang, Yu, Williams, Springman, Jeffery, Sprengeler, Estevez, Sampang, Shrader, Spencer, Young, McGrath, Katz: "Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein." dans: The Journal of biological chemistry, Vol. 280, Issue 49, pp. 41077-89, (2005) (PubMed).

Détails sur KLKB1

Antigène: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Autre désignation: KLKB1

Sujet: Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
Alias Symbols: KLK3, PPK
Protein Interaction Partner: TFPI2, HGFAC, SERPINA5, F12, KNG1, IGFBP3, HGF, MST1,
Protein Size: 638

Poids moléculaire: 28 kDa

ID gène: 3818

NCBI Accession: NM_000892, NP_000883

UniProt: P03952

Pathways: Système du Complément, Brown Fat Cell Differentiation