DYRK1A anticorps (N-Term)
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- Antigène Voir toutes DYRK1A Anticorps
- DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Lapin, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DYRK1A est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- INEVYYAKKK RRHQQGQGDD SSHKKERKVY NDGYDDDNYD YIVKNGEKWM
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against DYRK1A. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human DYRK1A
- Top Product
- Discover our top product DYRK1A Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 763 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))
- Autre désignation
- DYRK1A (DYRK1A Produits)
- Synonymes
- anticorps DYRK1A, anticorps dyrk, anticorps dyrk1, anticorps hp86, anticorps mnb, anticorps mnbh, anticorps DYRK, anticorps DYRK1, anticorps HP86, anticorps MNB, anticorps MNBH, anticorps MRD7, anticorps 2310043O08Rik, anticorps D16Ertd272e, anticorps D16Ertd493e, anticorps Dyrk, anticorps ENSMUSG00000074897, anticorps Gm10783, anticorps Mnbh, anticorps Mp86, anticorps mmb, anticorps PSK47, anticorps dual specificity tyrosine phosphorylation regulated kinase 1A, anticorps dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, anticorps dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a, anticorps dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A S homeolog, anticorps DYRK1A, anticorps dyrk1a, anticorps Dyrk1a, anticorps dyrk1a.S
- Sujet
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This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
Alias Symbols: DYRK, DYRK1, HP86, MNB, MNBH, MRD7
Protein Interaction Partner: SUMO1, UBC, CCDC8, FAM117A, FAM53C, SIPA1L1, DCAF7, TROAP, KIAA0232, DYNLL1, RBL2, RBL1, RB1, ABCD3, PRKAR1A, FNTB, FNTA, EP300, DYRK1A, CREBBP, CCNA2, RNF169, FAM117B, DYNLL2, GLCCI1, PPP1R3F, LZTS2, PRKACB, PRKACA, TRAF3, BARD1, SNCA, MAP3K5, APP, SMAD3
Protein Size: 763 - Poids moléculaire
- 85 kDa
- ID gène
- 1859
- NCBI Accession
- NM_001396, NP_001387
- UniProt
- Q13627
- Pathways
- Mitotic G1-G1/S Phases
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