RRM2 anticorps (N-Term)

N° du produit ABIN2782440

Cité dans 1 publication. Cet anticorps anti-RRM2 Polyclonal Lapin (ABIN2782440) détecte spécifiquement RRM2 dans WB. L’anticorps est réactif avec des échantillons de Humain, Rat, Cobaye, Cheval, Boeuf (Vache) et Chien.

Aperçu rapide pour RRM2 anticorps (N-Term) (ABIN2782440)

Antigène: RRM2 (Ribonucleotide Reductase M2 (RRM2))

Reactivité: Humain, Rat, Cobaye, Cheval, Boeuf (Vache), Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RRM2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RRM2 anticorps

Épitope: N-Term

Fonction: RRM2 Antibody - N-terminal region

Séquence: PALSGTRVLA SKTARRIFQE PTEPKTKAAA PGVEDEPLLR ENPRRFVIFP

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against RRM2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human RRM2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46031-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-RRM2 (ABIN2782440)

Lane, Yu, Lackey, Chen, Marzluff, Cook: "Cell cycle-regulated protein abundance changes in synchronously proliferating HeLa cells include regulation of pre-mRNA splicing proteins." dans: PLoS ONE, Vol. 8, Issue 3, pp. e58456, (2013) (PubMed).

Détails sur RRM2

Antigène: RRM2 (Ribonucleotide Reductase M2 (RRM2))

Autre désignation: RRM2

Sujet:

Targeted Subunit: M2

Background Information: RRM2 provides the precursors necessary for DNA synthesis. RRM2 catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RRM2 inhibits Wnt signaling.Ribonucleotide reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. It is composed of 2 non-identical subunits, proteins M1 and M2. Synthesis of M2 is regulated in a cell-cycle dependent fashion. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Ribonucleotide reductase M2

Alternative Symbols: R2, RR2, RR2M, C2orf48

Protein Name: Ribonucleoside-diphosphate reductase subunit M2

Poids moléculaire: 45kDa

ID gène: 6241

NCBI Accession: NP_001025

UniProt: P31350

Pathways: Mitotic G1-G1/S Phases