Lamin B1 anticorps (Middle Region)

N° du produit ABIN2782509

Cité dans 1 publication. Cet anticorps anti-Lamin B1 Polyclonal Lapin (ABIN2782509) détecte spécifiquement Lamin B1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cheval et Cobaye.

Aperçu rapide pour Lamin B1 anticorps (Middle Region) (ABIN2782509)

Antigène: Lamin B1 (LMNB1)

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Lamin B1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Lamin B1 anticorps

Épitope: Middle Region

Fonction: LMNB1 Antibody - middle region

Séquence: EEVAQRSTVF KTTIPEEEEE EEEAAGVVVE EELFHQQGTP RASNRSCAIM

Homologie: Cow: 86%, Dog: 100%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 91%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against LMNB1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human LMNB1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46137-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Lamin B1 (ABIN2782509)

Lee, Seng, Sekine, Hinton, Fu, Avraham, Avraham: "Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1." dans: PLoS medicine, Vol. 4, Issue 6, pp. e186, (2007) (PubMed).

Détails sur Lamin B1

Antigène: Lamin B1 (LMNB1)

Autre désignation: LMNB1

Sujet:

Background Information: LAMNB1 encodes for one of the two B type proteins of the nuclear lamina, B1. The Vertebrate lamins consist of two types, A and B. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression.The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Lamin B1

Alternative Symbols: LMN, ADLD, LMN2, LMNB, MCPH26

Protein Name: Lamin-B1

Poids moléculaire: 66kDa

ID gène: 4001

NCBI Accession: NP_005564

UniProt: P20700

Pathways: Apoptose, Caspase Cascade in Apoptosis