Lamin B2 anticorps (N-Term)

N° du produit ABIN2782594

Cité dans 2 publications. Cet anticorps anti-Lamin B2 Polyclonal Lapin (ABIN2782594) détecte spécifiquement Lamin B2 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Rat, Souris, Cheval, Boeuf (Vache), Cobaye et Lapin.

Aperçu rapide pour Lamin B2 anticorps (N-Term) (ABIN2782594)

Antigène: Lamin B2 (LMNB2)

Reactivité: Humain, Rat, Souris, Cheval, Boeuf (Vache), Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Lamin B2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Lamin B2 anticorps

Épitope: N-Term

Fonction: LMNB2 Antibody - N-terminal region

Séquence: MATPLPGRAG GPATPLSPTR LSRLQEKEEL RELNDRLAHY IDRVRALELE

Homologie: Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 85%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against LMNB2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human LMNB2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46356-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Lamin B2 (ABIN2782594)

Jacinto, Benner, Hetzer: "The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing." dans: Genes & development, Vol. 29, Issue 12, pp. 1224-38, (2015) (PubMed).

Tsai, Wang, Heidinger, Shumaker, Adam, Goldman, Zheng: "A mitotic lamin B matrix induced by RanGTP required for spindle assembly." dans: Science (New York, N.Y.), Vol. 311, Issue 5769, pp. 1887-93, (2006) (PubMed).

Détails sur Lamin B2

Antigène: Lamin B2 (LMNB2)

Autre désignation: LMNB2

Sujet:

Background Information: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. LMNB2 is one of the two B type proteins, B2.The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B2. This gene is in a head-to-tail orientation with the gene for the translocase of inner mitochondrial membrane 13 homolog gene.

Gene Name: Lamin B2

Alternative Symbols: EPM9, LMN2, LAMB2, MCPH27

Protein Name: Lamin-B2

Poids moléculaire: 68kDa

ID gène: 84823

NCBI Accession: NP_116126

UniProt: Q03252

Pathways: Apoptose, Caspase Cascade in Apoptosis