PCDHA4 anticorps (C-Term)

N° du produit ABIN2782799

Cet anticorps Lapin Polyclonal détecte spécifiquement PCDHA4 dans WB. Il présente une réactivité envers Humain, Cobaye, Rat, Boeuf (Vache), Chien, Cheval et Souris.

Aperçu rapide pour PCDHA4 anticorps (C-Term) (ABIN2782799)

Antigène: PCDHA4 (Protocadherin alpha 4 (PCDHA4))

Reactivité: Humain, Cobaye, Rat, Boeuf (Vache), Chien, Cheval, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PCDHA4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PCDHA4 anticorps

Épitope: C-Term

Séquence: SGYNAWLSYE LQPETASASI PFRVGLYTGE ISTTRALDET DAPRQRLLVL

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against PCDHA4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human PCDHA4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 947 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PCDHA4

Antigène: PCDHA4 (Protocadherin alpha 4 (PCDHA4))

Autre désignation: PCDHA4

Sujet: The gene encoding PCDHA4 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. PCDHA4 is a single-pass type I membrane protein. It contains 6 cadherin domains. PCDHA4 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Alias Symbols: CNR1, CNRN1, CRNR1, MGC138307, MGC142169, PCDH-ALPHA4
Protein Interaction Partner: SGTA, LRIF1, CCDC90B, RBM48, IGSF21, SETDB1, C14orf1, UNC119, GDF9, RELN, TLE1, TP53, GAPDH, EEF1A1, APLP1,
Protein Size: 947

Poids moléculaire: 99 kDa

ID gène: 56144

NCBI Accession: NM_018907, NP_061730

UniProt: Q9UN74