Transglutaminase 2 anticorps (N-Term)

N° du produit ABIN2782979

Cité dans 1 publication. Cet anticorps anti-Transglutaminase 2 Polyclonal Lapin (ABIN2782979) détecte spécifiquement Transglutaminase 2 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Lapin, Cobaye, Chien, Boeuf (Vache), Cheval et Porc.

Aperçu rapide pour Transglutaminase 2 anticorps (N-Term) (ABIN2782979)

Antigène: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Reactivité: Humain, Souris, Rat, Lapin, Cobaye, Chien, Boeuf (Vache), Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Transglutaminase 2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Transglutaminase 2 anticorps

Épitope: N-Term

Fonction: TGM2 Antibody - N-terminal region

Séquence: MAEELVLERC DLELETNGRD HHTADLCREK LVVRRGQPFW LTLHFEGRNY

Homologie: Cow: 93%, Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 79%, Pig: 93%, Rabbit: 93%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against TGM2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human TGM2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP47472-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Transglutaminase 2 (ABIN2782979)

Guise, Engel, Williams, Mahdi, Bidwell, Chade: "Biopolymer-delivered vascular endothelial growth factor improves renal outcomes following revascularization." dans: American journal of physiology. Renal physiology, Vol. 316, Issue 5, pp. F1016-F1025, (2019) (PubMed).

Détails sur Transglutaminase 2

Antigène: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Autre désignation: TGM2

Sujet:

Background Information: Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. TGM2 acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, TGM2 is the autoantigen implicated in celiac disease.Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)

Alternative Symbols: TGC, tTG, G(h), hTG2, TG(C)

Protein Name: Protein-glutamine gamma-glutamyltransferase 2

Poids moléculaire: 77kDa

ID gène: 7052

NCBI Accession: NP_004604

UniProt: P21980

Pathways: Tube Formation, Thromboxane A2 Receptor Signaling