NDE1 anticorps (Middle Region)

N° du produit ABIN2783161

Détail du produit anti-NDE1 anticorps

Antigène: NDE1

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NDE1 est non-conjugé

Application: Western Blotting (WB)

Séquence: AHRGPSSSLN TPGSFRRGLD DSTGGTPLTP AARISALNIV GDLLRKVGAL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Attributs du produit: This is a rabbit polyclonal antibody against NDE1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human NDE1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 335 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-NDE1 (ABIN2783161)

Burdick, Kamiya, Hodgkinson, Lencz, DeRosse, Ishizuka, Elashvili, Arai, Goldman, Sawa, Malhotra: "Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding." dans: Human molecular genetics, Vol. 17, Issue 16, pp. 2462-73, (2008) (PubMed).

Détails sur NDE1

Antigène: NDE1

Autre désignation: NDE1 (NDE1 Produits)

Synonymes: anticorps 2810027M15Rik, anticorps AU042936, anticorps AW822251, anticorps Nude, anticorps mNudE, anticorps HOM-TES-87, anticorps LIS4, anticorps NDE, anticorps NUDE, anticorps NUDE1, anticorps fb82g01, anticorps im:7141877, anticorps wu:fb82g01, anticorps zgc:114109, anticorps nudE neurodevelopment protein 1, anticorps Nde1, anticorps NDE1, anticorps nde1

Sujet: NDE1 is required for centrosome duplication and formation and function of the mitotic spindle. It is essential for the development of the cerebral cortex. NDE1 may regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex
Alias Symbols: FLJ20101, HOM-TES-87, NUDE, NUDE1, LIS4
Protein Interaction Partner: FAM9B, LZTS2, USHBP1, NDEL1, ZNF398, NDE1, WAC, UBQLN1, MED4, DISC1, TFIP11, CEP250, NDC80, ARNT2, BZRAP1, MKRN3, TTC1, TRIM27, REL, HOXA2, GOLGA2, AR, YWHAQ, PAFAH1B1, ZNF365, YWHAG, TUBG1, MAPK1, CDK1,
Protein Size: 335

Poids moléculaire: 38 kDa

ID gène: 54820

NCBI Accession: NM_017668, NP_060138