QPCT anticorps (Middle Region)

N° du produit ABIN2783489

L’anticorps Lapin Polyclonal anti-QPCT a été validé pour WB. Il convient pour détecter QPCT dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Mouton, Cobaye et Lapin.

Aperçu rapide pour QPCT anticorps (Middle Region) (ABIN2783489)

Antigène: QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Mouton, Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp QPCT est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-QPCT anticorps

Épitope: Middle Region

Séquence: SRHLAAKMAS TPHPPGARGT SQLHGMDLLV LLDLIGAPNP TFPNFFPNSA

Homologie: Cow: 86%, Dog: 79%, Guinea Pig: 93%, Horse: 79%, Human: 100%, Mouse: 79%, Rabbit: 93%, Rat: 100%, Sheep: 86%

Attributs du produit: This is a rabbit polyclonal antibody against QPCT. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human QPCT

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 361 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur QPCT

Antigène: QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))

Autre désignation: QPCT

Sujet: QPCT is responsible for the biosynthesis of pyroglutamyl peptides. QPCT has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. It also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. QPCT may be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86 % identical to that of bovine glutaminyl cyclase. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: GCT, QC, sQC
Protein Interaction Partner: CAND1, DCUN1D1, COPS5, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, NEDD8, UBC,
Protein Size: 361

Poids moléculaire: 38 kDa

ID gène: 25797

NCBI Accession: NM_012413, NP_036545

UniProt: Q16769