DISP1 anticorps (Middle Region)

N° du produit ABIN2784069

L’anticorps anti-DISP1 Polyclonal Lapin est utilisé pour la détection de DISP1 dans des échantillons de Humain, Souris, Rat, Lapin, Poisson zèbre (Danio rerio), Cheval et Porc. Il a été validé pour WB.

Aperçu rapide pour DISP1 anticorps (Middle Region) (ABIN2784069)

Antigène: DISP1 (Dispatched Homolog 1 (DISP1))

Reactivité: Humain, Souris, Rat, Lapin, Poisson zèbre (Danio rerio), Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DISP1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-DISP1 anticorps

Épitope: Middle Region

Fonction: DISP1 Antibody - middle region

Séquence: FVLCDVWNYT KFDKPHAETS ETVSITLQHA ALSMFVTSFT TAAAFYANYV

Homologie: Horse: 93%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 100%, Rat: 86%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against DISP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human DISP1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP50142-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur DISP1

Antigène: DISP1 (Dispatched Homolog 1 (DISP1))

Autre désignation: DISP1

Sujet:

Background Information: DISP1 functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal.The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo.

Gene Name: Dispatched homolog 1 (Drosophila)

Alternative Symbols: DISPA

Protein Name: Protein dispatched homolog 1

Poids moléculaire: 171 kDa

ID gène: 84976

NCBI Accession: NP_116279

UniProt: Q96F81

Pathways: Signalisation Hedgehog