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SIGLEC10 anticorps (Middle Region)

SIGLEC10 Reactivité: Humain, Chien WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2784077
  • Antigène Voir toutes SIGLEC10 Anticorps
    SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))
    Épitope
    • 15
    • 8
    • 7
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Middle Region
    Reactivité
    • 59
    • 20
    • 6
    • 4
    • 4
    Humain, Chien
    Hôte
    • 47
    • 12
    • 1
    Lapin
    Clonalité
    • 48
    • 12
    Polyclonal
    Conjugué
    • 17
    • 8
    • 7
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SIGLEC10 est non-conjugé
    Application
    • 48
    • 28
    • 8
    • 6
    • 6
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Séquence
    CHVDFSRKGV SAQRTVRLRV AYAPRDLVIS ISRDNTPALE PQPQGNVPYL
    Homologie
    Dog: 79%, Human: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against SIGLEC10. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human SIGLEC10
    Top Product
    Discover our top product SIGLEC10 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 697 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Szafranski, Schindler, Taudien, Hiller, Huse, Jahn, Schreiber, Backofen, Platzer: "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns." dans: Genome biology, Vol. 8, Issue 8, pp. R154, (2008) (PubMed).

  • Antigène
    SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))
    Autre désignation
    SIGLEC10 (SIGLEC10 Produits)
    Synonymes
    anticorps PRO940, anticorps SIGLEC-10, anticorps SLG2, anticorps Siglecg, anticorps SIGLEC10, anticorps slg2, anticorps pro940, anticorps siglec-10, anticorps sialic acid binding Ig like lectin 10, anticorps sialic acid binding Ig-like lectin 10, anticorps sialic acid-binding Ig-like lectin 10, anticorps SIGLEC10, anticorps Siglec10, anticorps LOC484343, anticorps LOC100066644, anticorps siglec10, anticorps LOC100513863, anticorps LOC100340374
    Sujet
    SIGLEC10 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. SIGLEC10 preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, SIGLEC10 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-653 AC008750.9 90495-91147 c 654-760 DA387605.1 391-497 761-2959 AF301007.1 262-2460 2960-3794 AY358337.1 1930-2764
    Alias Symbols: MGC126774, PRO940, SIGLEC-10, SLG2
    Protein Interaction Partner: FLNA, PTPN6,
    Protein Size: 697
    Poids moléculaire
    76 kDa
    ID gène
    89790
    NCBI Accession
    NM_033130, NP_149121
    UniProt
    Q96LC7
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