TMEM123 anticorps (C-Term)

N° du produit ABIN2784103

Cet anticorps Lapin Polyclonal détecte spécifiquement TMEM123 dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour TMEM123 anticorps (C-Term) (ABIN2784103)

Antigène: TMEM123 (Transmembrane Protein 123 (TMEM123))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMEM123 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TMEM123 anticorps

Épitope: C-Term

Fonction: TMEM123 Antibody - C-terminal region

Séquence: SSVTITTTMH SEAKKGSKFD TGSFVGGIVL TLGVLSILYI GCKMYYSRRG

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against TMEM123. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human TMEM123

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP50227-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur TMEM123

Antigène: TMEM123 (Transmembrane Protein 123 (TMEM123))

Autre désignation: TMEM123

Sujet:

Background Information: TMEM123 is a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. TMEM123 is proposed to function as a cell surface receptor that mediates cell death.This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.

Gene Name: Transmembrane protein 123

Alternative Symbols: KCT3, PORMIN, PORIMIN

Protein Name: Porimin

Poids moléculaire: 19kDa

ID gène: 114908

NCBI Accession: NP_443164

UniProt: Q8N131

Pathways: Regulation of Cell Size