NUMA1 anticorps (C-Term)

N° du produit ABIN2784222

Détail du produit anti-NUMA1 anticorps

Antigène: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Cobaye, Cheval, Chien, Boeuf (Vache), Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUMA1 est non-conjugé

Application: Western Blotting (WB)

Séquence: AQRLQAQLNE LQAQLSQKEQ AAEHYKLQME KAKTHYDAKK QQNQELQEQL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against NUMA1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human NUMA1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 2115 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-NUMA1 (ABIN2784222)

Kilpivaara, Rantanen, Tamminen, Aittomäki, Blomqvist, Nevanlinna: "Comprehensive analysis of NuMA variation in breast cancer." dans: BMC cancer, Vol. 8, pp. 71, (2008) (PubMed).

Détails sur NUMA1

Antigène: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Autre désignation: NUMA1 (NUMA1 Produits)

Synonymes: anticorps NUMA, anticorps 6720401E04Rik, anticorps AA764025, anticorps AL022610, anticorps AU014979, anticorps NUMA1, anticorps NuMA, anticorps SP-H, anticorps numa, anticorps numa1, anticorps nuclear mitotic apparatus protein 1, anticorps nuclear mitotic apparatus protein 1 S homeolog, anticorps NUMA1, anticorps Numa1, anticorps numa1, anticorps numa1.S

Sujet: NuMA is a structural element in maintaining nuclear integrity. A critical spindle pole-associated mechanism, called the END (Emi1/NuMA/dynein-dynactin) network, spatially restricts APC/C activity in early mitosis. The entire coding region and exon-intron boundaries of NuMa were screened in 92 familial breast cancer patients. But the results do not support the role of NuMA variants as breast cancer susceptibility alleles.
Alias Symbols: NUMA
Protein Interaction Partner: CCDC57, GMCL1, BRAP, DVL3, DVL2, DVL1, UBC, LGR4, ERG, RPA3, RPA2, RPA1, RNF2, EZH2, BMI1, SUZ12, EED, YWHAQ, LMNA, CBX6, WHSC1, HSP90AB1, HSP90AA1, ESR1, CDK6, VCP, SMURF1, MDC1, TP53BP1, ECT2, NCSTN, DDB1, EMILIN1, DYNLL1, RAE1, NUP98, CDK2, TERF2IP, TE
Protein Size: 2115

Poids moléculaire: 238 kDa

ID gène: 4926

NCBI Accession: NM_006185, NP_006176

UniProt: Q14980

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, M Phase