CK1 epsilon anticorps (N-Term)

N° du produit ABIN2784724

Cet anticorps Lapin Polyclonal détecte spécifiquement CK1 epsilon dans WB. Il présente une réactivité envers Humain, Souris, Rat, Chien, Mouton, Lapin, Cobaye, Cheval, Boeuf (Vache), Saccharomyces cerevisiae et Poisson zèbre (Danio rerio) et a été mentionné dans 1 publication.

Aperçu rapide pour CK1 epsilon anticorps (N-Term) (ABIN2784724)

Antigène: CK1 epsilon (CSNK1E) (Casein Kinase 1, epsilon (CSNK1E))

Reactivité: Humain, Souris, Rat, Chien, Mouton, Lapin, Cobaye, Cheval, Boeuf (Vache), Saccharomyces cerevisiae, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CK1 epsilon est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CK1 epsilon anticorps

Épitope: N-Term

Séquence: MELRVGNKYR LGRKIGSGSF GDIYLGANIA SGEEVAIKLE CVKTKHPQLH

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Yeast: 93%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against CSNK1E. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CSNK1E

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 416 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-CK1 epsilon (ABIN2784724)

Levran, Londono, OHara, Nielsen, Peles, Rotrosen, Casadonte, Linzy, Randesi, Ott, Adelson, Kreek: "Genetic susceptibility to heroin addiction: a candidate gene association study." dans: Genes, brain, and behavior, Vol. 7, Issue 7, pp. 720-9, (2009) (PubMed).

Détails sur CK1 epsilon

Antigène: CK1 epsilon (CSNK1E) (Casein Kinase 1, epsilon (CSNK1E))

Autre désignation: CSNK1E

Sujet: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. CSNK1E can phosphorylate a large number of proteins. CSNK1E participates in Wnt signaling and is the central component of the circadian clock. It may act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. CSNK1E inhibits cytokine-induced granuloytic differentiation.The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: HCKIE, MGC10398, CKIepsilon
Protein Interaction Partner: DVL3, TIAM1, UBC, REST, ZSWIM8, TAZ, SAV1, DVL2, ADAM22, SNX24, AHCYL2, PER1, MCC, HMMR, TCEB2, STK3, SEC13, CSNK1D, CSNK1A1, CRY1, ACACA, FAM83H, FAM83B, VPS13B, FAM199X, KLHDC3, FAM110B, FAM110A, FAM83D, C2orf44, SNX22, STOX2, UNC45A, PPP6R3, WDR5, SDCC
Protein Size: 416

Poids moléculaire: 47 kDa

ID gène: 1454

NCBI Accession: NM_001894, NP_001885

UniProt: P49674

Pathways: Signalisation Hedgehog, M Phase