CK1 epsilon anticorps (N-Term)

N° du produit ABIN2784724

Détail du produit anti-CK1 epsilon anticorps

Antigène: CK1 epsilon (CSNK1E) (Casein Kinase 1, epsilon (CSNK1E))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Mouton, Lapin, Boeuf (Vache), Cobaye, Cheval, Saccharomyces cerevisiae, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CK1 epsilon est non-conjugé

Application: Western Blotting (WB)

Séquence: MELRVGNKYR LGRKIGSGSF GDIYLGANIA SGEEVAIKLE CVKTKHPQLH

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Yeast: 93%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against CSNK1E. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CSNK1E

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 416 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-CK1 epsilon (ABIN2784724)

Levran, Londono, OHara, Nielsen, Peles, Rotrosen, Casadonte, Linzy, Randesi, Ott, Adelson, Kreek: "Genetic susceptibility to heroin addiction: a candidate gene association study." dans: Genes, brain, and behavior, Vol. 7, Issue 7, pp. 720-9, (2009) (PubMed).

Détails sur CK1 epsilon

Antigène: CK1 epsilon (CSNK1E) (Casein Kinase 1, epsilon (CSNK1E))

Autre désignation: CSNK1E (CSNK1E Produits)

Synonymes: anticorps CKIepsilon, anticorps HCKIE, anticorps CKIe, anticorps ck1-epsilon, anticorps ck1epsilon, anticorps hckie, anticorps dco, anticorps fj38c01, anticorps wu:fj38c01, anticorps wu:fj62a04, anticorps zgc:77310, anticorps AI426939, anticorps AI551861, anticorps AW457082, anticorps CK1epsilon, anticorps KC1epsilon, anticorps tau, anticorps ckie, anticorps CSNK1E, anticorps Csnk1e, anticorps CKI-epsilon, anticorps 0538/13, anticorps 0915/10, anticorps 1396/02, anticorps 1447/01, anticorps 1460/09, anticorps CG2048, anticorps CK1delta/epsilon, anticorps DBT, anticorps DBT/CK1epsilon, anticorps DCO, anticorps DCO/CKIe, anticorps Dbt, anticorps Dco, anticorps Dco/CK1, anticorps Dmel\CG2048, anticorps dCKIepsilon, anticorps dbt, anticorps dco-1, anticorps ddbt, anticorps l(3)S053813, anticorps l(3)S144701, anticorps l(3)dco, anticorps l(3)dco-1, anticorps l(3)discs overgrown, anticorps l(3)discs overgrown-1, anticorps l(3)j3B9, anticorps l(3)rK215, anticorps casein kinase 1 epsilon, anticorps casein kinase 1, epsilon, anticorps casein kinase 1 epsilon L homeolog, anticorps casein kinase I isoform epsilon, anticorps casein kinase I epsilon, anticorps casein kinase I, anticorps LOC400927-CSNK1E readthrough, anticorps discs overgrown, anticorps CSNK1E, anticorps csnk1e, anticorps Csnk1e, anticorps csnk1e.L, anticorps LOC443240, anticorps NAEGRDRAFT_82890, anticorps LOC100407384, anticorps LOC100523244, anticorps LOC100607246, anticorps LOC100727500, anticorps LOC400927-CSNK1E, anticorps dco

Sujet: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. CSNK1E can phosphorylate a large number of proteins. CSNK1E participates in Wnt signaling and is the central component of the circadian clock. It may act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. CSNK1E inhibits cytokine-induced granuloytic differentiation.The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: HCKIE, MGC10398, CKIepsilon
Protein Interaction Partner: DVL3, TIAM1, UBC, REST, ZSWIM8, TAZ, SAV1, DVL2, ADAM22, SNX24, AHCYL2, PER1, MCC, HMMR, TCEB2, STK3, SEC13, CSNK1D, CSNK1A1, CRY1, ACACA, FAM83H, FAM83B, VPS13B, FAM199X, KLHDC3, FAM110B, FAM110A, FAM83D, C2orf44, SNX22, STOX2, UNC45A, PPP6R3, WDR5, SDCC
Protein Size: 416

Poids moléculaire: 47 kDa

ID gène: 1454

NCBI Accession: NM_001894, NP_001885

UniProt: P49674

Pathways: Signalisation Hedgehog, M Phase