TdT anticorps (N-Term)

N° du produit ABIN2784740

L’anticorps anti-TdT Polyclonal Lapin est utilisé pour la détection de TdT dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Cheval, Chien, Cobaye, Porc et Lapin. Il a été validé pour WB.

Aperçu rapide pour TdT anticorps (N-Term) (ABIN2784740)

Antigène: TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval, Chien, Cobaye, Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TdT est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TdT anticorps

Épitope: N-Term

Fonction: DNTT Antibody - N-terminal region

Séquence: FQDLVVFILE KKMGTTRRAF LMELARRKGF RVENELSDSV THIVAENNSG

Homologie: Cow: 100%, Dog: 79%, Guinea Pig: 82%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against DNTT. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human DNTT

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP52031-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur TdT

Antigène: TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

Autre désignation: DNTT

Sujet:

Background Information: DNTT is a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, DNTT is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

Gene Name: Deoxynucleotidyltransferase, terminal

Alternative Symbols: TDT

Protein Name: DNA nucleotidylexotransferase

Poids moléculaire: 58kDa

ID gène: 1791

NCBI Accession: NP_004079

UniProt: P04053

Pathways: Réparation de l'ADN