TdT anticorps (N-Term)

N° du produit ABIN2784740

Détail du produit anti-TdT anticorps

Antigène: TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Cheval, Chien, Porc, Lapin, Boeuf (Vache), Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TdT est non-conjugé

Application: Western Blotting (WB)

Séquence: FQDLVVFILE KKMGTTRRAF LMELARRKGF RVENELSDSV THIVAENNSG

Homologie: Cow: 100%, Dog: 79%, Guinea Pig: 82%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against DNTT. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human DNTT

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 509 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TdT

Antigène: TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

Autre désignation: DNTT (DNTT Produits)

Synonymes: anticorps TdT, anticorps TDT, anticorps BB160593, anticorps Tdt, anticorps dntt-A, anticorps dntt, anticorps DNA nucleotidylexotransferase, anticorps deoxynucleotidyltransferase, terminal, anticorps DNA nucleotidylexotransferase L homeolog, anticorps terminal deoxynucleotidyl transferase, anticorps DNTT, anticorps dntt, anticorps Dntt, anticorps dntt.L, anticorps tdt

Sujet: DNTT is a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, DNTT is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
Alias Symbols: TDT
Protein Interaction Partner: REL, APOA1, DNTTIP1, UBC, PRPF19, DNTTIP2, PCNA, XRCC6, ABTB2, CUL3,
Protein Size: 509

Poids moléculaire: 58 kDa

ID gène: 1791

NCBI Accession: NM_004088, NP_004079

UniProt: P04053

Pathways: Réparation de l'ADN