PARK2 Co-Regulated (PACRG) (Middle Region) anticorps

Détails pour le produit réf. ABIN2785168
Antigène
  • PACRG
  • GLUP
  • HAK005771
  • PARK2CRG
  • RP3-495O10.2
  • zgc:101786
  • RGD1561027
  • 1700008H23Rik
  • parkin coregulated
  • PARK2 co-regulated
  • PARK2 coregulated
  • PACRG
  • pacrg
  • Pacrg
Épitope
Middle Region
9
9
8
7
3
1
1
Reactivité
Boeuf (Vache), Cobaye, Cheval, Humain, Souris, Lapin, Rat (Rattus), Poisson zèbre (Danio rerio)
48
20
20
5
2
1
1
1
1
Hôte
Lapin
47
1
Clonalité
Polyclonal
Conjugué
Inconjugué
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
36
23
14
6
5
4
2
Options
Immunogène The immunogen is a synthetic peptide directed towards the middle region of human PACRG
Blocking Peptide Blocking peptide for this product available: ABIN981300
Séquence GAIMARCNLD HLGSSDPPTS ASQVAEIIVN SGDGIDYSQQ KRENIGDLIQ
Homologie Cow: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
Attributs du produit This is a rabbit polyclonal antibody against PACRG. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Antigène
Autre désignation PACRG (PACRG Antibody Extrait)
Sujet PACRG is a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death.This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: FLJ32724, GLUP, HAK005771, PARK2CRG, RP3-495O10.2
Protein Interaction Partner: UBC, TUBB, HOPX, CCT5, CCT8, CCT2, CCT4, CCT7, STUB1, TUBA1A, VCP, CCT3, TCP1, PARK2, HSP90AA1, HSPA4, DNAJA1, GPR37, CCT6A, APP,
Protein Size: 296
Poids moléculaire 33 kDa
ID gène 135138
NCBI Accession NM_152410, NP_689623
UniProt Q96M98
Indications d'application Optimal working dilutions should be determined experimentally by the investigator.
Commentaires

Antigen size: 296 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freeze-thaw cycles.
Stock -20 °C
Stockage commentaire For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Images (Fournisseur)
Western Blotting (WB) image for anti-PARK2 Co-Regulated (PACRG) (Middle Region) antibody (ABIN2785168) WB Suggested Anti-PACRG Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive ...
Produit citée dans: Taylor, Song, Huang, Farrer, Delatycki, Halliday, Lockhart: "Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases." dans: Neurobiology of disease, Vol. 27, Issue 2, pp. 238-47, 2007 (PubMed).

Verrengia Guerrero, Taylor, Simkiss: "Modelling 2,4-dichlorophenol bioavailability and bioaccumulation by the freshwater fingernail clam Sphaerium corneum using artificial particles and humic acids." dans: Environmental pollution (Barking, Essex : 1987), Vol. 145, Issue 1, pp. 238-44, 2006 (PubMed).

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