PACRG anticorps (Middle Region)

N° du produit ABIN2785168

Cité dans 2 publications. Cet anticorps anti-PACRG Polyclonal Lapin (ABIN2785168) détecte spécifiquement PACRG dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Poisson zèbre (Danio rerio), Boeuf (Vache), Cheval, Cobaye et Lapin.

Aperçu rapide pour PACRG anticorps (Middle Region) (ABIN2785168)

Antigène: PACRG (PARK2 Co-Regulated (PACRG))

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Boeuf (Vache), Cheval, Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PACRG est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PACRG anticorps

Épitope: Middle Region

Fonction: PACRG Antibody - middle region

Séquence: GAIMARCNLD HLGSSDPPTS ASQVAEIIVN SGDGIDYSQQ KRENIGDLIQ

Homologie: Cow: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PACRG. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PACRG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP52953-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PACRG (ABIN2785168)

Taylor, Song, Huang, Farrer, Delatycki, Halliday, Lockhart: "Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases." dans: Neurobiology of disease, Vol. 27, Issue 2, pp. 238-47, (2007) (PubMed).

Verrengia Guerrero, Taylor, Simkiss: "Modelling 2,4-dichlorophenol bioavailability and bioaccumulation by the freshwater fingernail clam Sphaerium corneum using artificial particles and humic acids." dans: Environmental pollution (Barking, Essex : 1987), Vol. 145, Issue 1, pp. 238-44, (2006) (PubMed).

Détails sur PACRG

Antigène: PACRG (PARK2 Co-Regulated (PACRG))

Autre désignation: PACRG

Sujet:

Background Information: PACRG is a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death.This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: PARK2 co-regulated

Alternative Symbols: GLUP, PACRG2.1, PARK2CRG, HAK005771

Protein Name: Parkin coregulated gene protein

Poids moléculaire: 33kDa

ID gène: 135138

NCBI Accession: NP_689623

UniProt: Q96M98