RDH12 anticorps (Middle Region)

N° du produit ABIN2785175

Il existe 1 publication pour ce produit. L’anticorps anti-RDH12 Polyclonal Lapin est utilisé pour la détection de RDH12 dans des échantillons de Humain, Porc, Rat et Chien. Il a été validé pour WB.

Aperçu rapide pour RDH12 anticorps (Middle Region) (ABIN2785175)

Antigène: RDH12 (Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12))

Reactivité: Humain, Porc, Rat, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RDH12 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RDH12 anticorps

Épitope: Middle Region

Fonction: RDH12 Antibody - middle region

Séquence: HIGKIPFHDL QSEKRYSRGF AYCHSKLANV LFTRELAKRL QGTGVTTYAV

Homologie: Dog: 93%, Human: 100%, Pig: 79%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against RDH12. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human RDH12

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP52972-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-RDH12 (ABIN2785175)

Sun, Gerth, Maeda, Lodowski, Van Der Kraak, Saperstein, Héon, Palczewski: "Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations." dans: Vision research, Vol. 47, Issue 15, pp. 2055-66, (2007) (PubMed).

Détails sur RDH12

Antigène: RDH12 (Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12))

Autre désignation: RDH12

Sujet:

Background Information: RDH12 is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. RDH12 also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3).The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3).

Gene Name: Retinol dehydrogenase 12 (all-trans/9-cis/11-cis)

Alternative Symbols: RP53, LCA13, SDR7C2

Protein Name: Retinol dehydrogenase 12

Poids moléculaire: 35kDa

ID gène: 145226

NCBI Accession: NP_689656

UniProt: Q96NR8