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Sphingomyelin Synthase 2 anticorps (N-Term)

SGMS2 Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2785218
  • Antigène Voir toutes Sphingomyelin Synthase 2 (SGMS2) Anticorps
    Sphingomyelin Synthase 2 (SGMS2)
    Épitope
    • 10
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 24
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Lapin, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio)
    Hôte
    • 22
    • 2
    Lapin
    Clonalité
    • 22
    • 2
    Polyclonal
    Conjugué
    • 15
    • 3
    • 2
    • 2
    • 1
    • 1
    Cet anticorp Sphingomyelin Synthase 2 est non-conjugé
    Application
    • 19
    • 13
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Séquence
    KFPLEWWKTG IAFIYAVFNL VLTTVMITVV HERVPPKELS PPLPDKFFDY
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
    Attributs du produit
    This is a rabbit polyclonal antibody against SGMS2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human SGMS2
    Top Product
    Discover our top product SGMS2 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 365 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    Sphingomyelin Synthase 2 (SGMS2)
    Autre désignation
    SGMS2 (SGMS2 Produits)
    Synonymes
    anticorps SMS2, anticorps 4933405A16Rik, anticorps 5133401H06Rik, anticorps AI854299, anticorps RGD1305778, anticorps spermatin, anticorps sphingomyelin synthase 2, anticorps sgms2, anticorps SGMS2, anticorps Sgms2
    Sujet
    SGMS2 is a bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. SGMS2 directly and specifically recognizes the choline head group on the substrate. SGMS2 also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. SGMS2 does not function strictly as a SM synthase. SGMS2 is required for cell growth.Sphingomyelin (SM) is a major component of plasma membranes. It is preferentially concentrated in the outer leaflet and has a role in the formation of lipid rafts. SM synthases (EC 2.7.8.27), such as SGMS2, produce SM in the lumen of the Golgi and on the cell surface through the transfer of phosphocholine from phosphatidylcholine onto ceramide, yielding diacylglycerol as a side product (Huitema et al., 2004 [PubMed 14685263]).[supplied by OMIM]. Sequence Note: removed 3 bases from the 5' end that did not align to the reference genome assembly. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2142 BC041369.2 4-2145
    Alias Symbols: MGC26963, SMS2
    Protein Interaction Partner: UBC,
    Protein Size: 365
    Poids moléculaire
    42 kDa
    ID gène
    166929
    NCBI Accession
    NM_152621, NP_689834
    UniProt
    Q8NHU3
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