SOCS7 anticorps (N-Term)

N° du produit ABIN2785524

Cet anticorps anti-SOCS7 est un anticorps Lapin Polyclonal détectant SOCS7 dans WB. Adapté pour Humain, Souris, Rat, Boeuf (Vache), Lapin et Porc.

Aperçu rapide pour SOCS7 anticorps (N-Term) (ABIN2785524)

Antigène: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOCS7 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SOCS7 anticorps

Épitope: N-Term

Séquence: LDPKALPPGL ALERTWGPAA GLEAQLAALG LGQPAGPGVK TVGGGCCPCP

Homologie: Cow: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SOCS7. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SOCS7

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 581 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SOCS7

Antigène: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Autre désignation: SOCS7

Sujet: SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Alias Symbols: NAP4, NCKAP4
Protein Interaction Partner: SEPT6, SORBS3, STAT5A, STAT3, CUL5, IRS4, PIK3R2, TUBB4B, TUBA1A, IRS2, NCK1, PLCG1, PIK3R1, EGFR, GRB2,
Protein Size: 581

Poids moléculaire: 64 kDa

ID gène: 30837

NCBI Accession: NM_014598, NP_055413

UniProt: O14512