ULK1 anticorps (N-Term)

N° du produit ABIN2785618

Détail du produit anti-ULK1 anticorps

Antigène: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ULK1 est non-conjugé

Application: Western Blotting (WB)

Séquence: PEVIMSQHYD GKADLWSIGT IVYQCLTGKA PFQASSPQDL RLFYEKNKTL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ULK1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human ULK1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ULK1

Antigène: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Autre désignation: ULK1 (ULK1 Produits)

Synonymes: anticorps ATG1, anticorps ATG1A, anticorps UNC51, anticorps Unc51.1, anticorps hATG1, anticorps si:dkey-11o18.7, anticorps ulk1, anticorps ULK1, anticorps AU041434, anticorps mKIAA0722, anticorps zgc:195008, anticorps unc-51 like autophagy activating kinase 1, anticorps unc-51 like kinase 1, anticorps unc-51 like autophagy activating kinase 1a, anticorps ULK1, anticorps Ulk1, anticorps ulk1b, anticorps ulk1a

Sujet: ULK1 is a serine/threonine-protein kinase involved in autophagy in response to starvation. It acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. It is activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. It may phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences and plays a role early in neuronal differentiation and is required for granule cell axon formation.
Alias Symbols: ATG1, ATG1A, UNC51, Unc51.1, hATG1
Protein Interaction Partner: SESN2, SQSTM1, ATG16L1, EXOC8, EXOC2, BECN1, RALB, AMBRA1, ULK1, UBC, TRAF6, MBP, ATG13, MAP1LC3C, MAP1LC3A, MAP1LC3B, GABARAPL1, GABARAPL2, GABARAP, MLST8, RPTOR, MTOR, PPP1CA, ATG4B, CDC37, G3BP1, RB1CC1, USP10, PRKAG1, PRKAB2, PRKAA2, PRKAA1, SYNGAP1,
Protein Size: 1050

Poids moléculaire: 112 kDa

ID gène: 8408

NCBI Accession: NM_003565, NP_003556

UniProt: O75385

Pathways: Regulation of Cell Size, Autophagy